Human Chorionic Gonadotropin- Gene Expression in First Trimester Placenta

Human chorionic gonadotropin-beta gene expression in first trimester placenta.

The hCGbeta gene family contains six genes linked in tandem on chromosome 19 and labeled beta genes 7, 8, 5, 1, 2, and 3. Previous studies on a small number of placentas have indicated that beta gene 5 was the most highly expressed gene during the first trimester of pregnancy, followed by genes 3 and 8. Beta genes 7, 1, and 2 were expressed at very low levels. The purpose of this study was to d...

Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study

BACKGROUND The human placenta is a rapidly developing organ that undergoes structural and functional changes throughout the pregnancy. Our objectives were to investigate the differences in global gene expression profile, the expression of imprinted genes and the effect of smoking in first and third trimester normal human placentas. MATERIALS AND METHODS Placental samples were collected from 2...

Placenta Percreta Resulting in Incomplete Spontaneous Abortion in First Trimester

Invasive trophoblast antigen (hyperglycosylated human chorionic gonadotropin) as a first-trimester serum marker for Down syndrome.

and basic urine analysis. All were asymptomatic and underwent a complete examination by a cardiologist, including a visit, standard 12-lead electrocardiogram, Doppler echocardiographic examination, and a bicycle stress test (when older than 50 years), which excluded silent heart disease. The median ACCESS and TRIAGE BNP concentrations were 10.5 ng/L (range, 1–53 ng/L; 97.5th percentile, 45 ng/L...

A molar pregnancy detected by following beta-human chorionic gonadotropin levels after a first trimester loss.

This case report summarizes the sequence of events that led to the detection of a molar pregnancy missed by ultrasound and initial pathology examinations. This patient illustrates that following serial quantitative beta-human chorionic gonadotropin (B-hCG) levels after spontaneous, therapeutic, and elective abortions will help detect potentially life-threatening molar and ectopic pregnancies. F...